the Stakeholder Panel on Dietary Supplements

Existing Kavalactone Methods

▪ HPTLC ▪ USP, HPTLC Association ▪ Generally used for ID and qualitative purposes

▪ Detection of flavokavins A, B, C ▪ Validation of High-Performance Thin-Layer Chromatographic Methods for the Identification of Botanicals in a cGMP Environment ▪ J AOAC Int. 2008;91(1):13–20.

Existing Kavalactone Methods ▪ RP HPLC - MS ▪ Baseline separations of six major kavalactones ▪ Reports by the major US extract producers

▪ East Earth Herb 1997 ▪ Madis Botanicals 1998 ▪ Then Pure World ▪ Then Naturex ▪ USP (UV) NLT 4.5%