the Stakeholder Panel on Dietary Supplements

Existing Kavalactone Methods

▪ Supercritical Fluid Chromatography ▪ CO 2

& methanol w/diethylamine

▪ Commercial column ▪ LOD below 1.5 ng on-column ▪ Baseline separation ▪ Under 4 minute run time ▪ Method of choice?

Challenges

▪ Cost effectively addressing stakeholder needs ▪ Focus methods solely on kavalactone quantitation or include other considerations for kava quality control? ▪ Deciding to accept methods that may help differentiate cultivars (noble vs. two day) based on chemotype or presence of flavokavains A, B, and C ▪ Include qualitative methods? ▪ Obtain sufficient stakeholder engagement to best understand needs of the whole kava industry supply chain ▪ Collaborate with WHO Proposal to develop a Regional Codex Standard for Kava Products for Use as a Beverage?